Bayesian hidden Markov model for DNA sequence segmentation: A prior sensitivity analysis
نویسندگان
چکیده
منابع مشابه
Bayesian hidden Markov model for DNA sequence segmentation: A prior sensitivity analysis
The focus of this paper is on the sensitivity to the specification of the prior in a hidden Markov model describing homogeneous segments of DNA sequences. An intron from the chimpanzee α-fetoprotein gene, which plays an important role in embryonic development in mammals is analysed. Three main aims are considered : (i) to assess the sensitivity to prior specification in Bayesian hidden Markov m...
متن کاملBayesian hidden Markov Model for DNA segmentation : A prior sensitivity analysis
The focus of this paper is on the sensitivity to the specification of the prior in a hidden Markov model describing homogeneous segments of DNA sequences. An intron from the chimpanzee α-fetoprotein gene, which plays an important role in embryonic development in mammals is analysed. Three main aims are considered : (i) to assess the sensitivity to prior specification in Bayesian hidden Markov m...
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We have developed a new method for the analysis of DNA sequences. The method consists of the Hidden Markov Model (HMM) [1] and Genetic Algorithm (GA) [2], and can identify conserved patterns, can estimate the distances between the patterns and can classify the sequences. We have applied the developed method to the extraction of conserved patterns in the vicinity of the 5' end of yeast intron DN...
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ژورنال
عنوان ژورنال: Computational Statistics & Data Analysis
سال: 2009
ISSN: 0167-9473
DOI: 10.1016/j.csda.2008.07.007